Amucogen Special Precautions

Patients with bronchial asthma must be closely monitored during therapy. If bronchospasm occurs, the use of acetylcysteine must be stopped immediately and appropriate treatment initiated.
Caution is advised when using this product in patients with a history of ulcers, particularly if additional drugs are being taken that are known to irritate the mucous membranes of the gastrointestinal tract.
The use of acetylcysteine, especially in early treatment can lead to liquefaction and thus to an increase in volume of bronchial secretions. If the patient is unable to expectorate (sufficiently expectorate), appropriate measures (such as drainage and aspiration) should be performed.
The occurrence of severe skin reactions such as Stevens-Johnson syndrome and Lyell's syndrome has very rarely been reported in temporal connection with the use of acetylcysteine. If cutaneous and mucosal changes newly occur, medical advice should be sought without delay and use if acetylcysteine be terminated. (See also Adverse Reactions.)
Caution is advised in patients with histamine intolerance. Treatment with acetylcysteine for longer periods should be avoided in such patients, as acetylcysteine affects histamine metabolism and can result in symptoms of intolerance (e.g. headache, runny nose, itching).
Effects on ability to drive and use machines: Acetylcysteine has no known effect on the ability to drive and use machines.
Use in Children: Children and adolescents: Mucolytics can result in blockage of the respiratory tract in children under 2 years of age, due to the characteristics of their respiratory tract and their limited ability to cough up mucus. Therefore, mucolytics must not be used in children under 2 years of age (see Contraindications).