Amlotitan Drug Interactions

Rifampicin: Rifampicin, an inducer of drug metabolism, decreased the concentrations of Losartan and its active metabolite.
Fluconazole: Fluconazole, an inhibitor of cytochrome P4502C9, decreased active metabolite concentration and increased Losartan concentration.
Agents that increases Serum Potassium: As with other drugs that block angiotensin II or its effects, concomitant use of potassium-sparing diuretics, potassium supplements or salt substitutes containing potassium may lead to increase in serum potassium.
Lithium: Losartan reduces lithium excretion; hence, serum lithium levels should be monitored carefully if lithium salts are to be co-administered with this combination.
Non-Steroidal Anti-Inflammatory Agents (NSAIDs) including Selective Cyclooxygenase-2 inhibitors: In some patients with compromised renal function who are being treated with NSAIDs, including those that selectively inhibit cyclooxygenase-2 inhibitors (COX-2 inhibitors), the co-administration of Losartan may result in a further deterioration of renal function. These effects are reversible. Reports suggest that NSAIDs, including selective COX-2 inhibitors may diminish the antihypertensive effect of Losartan. This interaction should be given consideration in patients taking NSAIDs, including selective COX-2 inhibitors, concomitantly with this combination of Losartan and Amlodipine.