Individualized dosage. Adult Initial stabilization: Initially 200 mg tid for 1 wk, then reduce to 200 mg bid. Maintenance: 200 mg daily. ChildnPO Loading dose: 10-20 mg/kg/day (500 mg/m2/day) for 7-10 days. Maintenance: Individualized dosage. 5-10 mg/kg/day (250 mg/m2/day). IV Loading dose: 5 mg/kg over 20 min to 2 hr. Maintenance: 10-15 mg/kg/day few hrs to several days. If needed, oral therapy may be initiated concomitantly at the usual loading dose.
View Amiron overdosage for action to be taken in the event of an overdose.
Administration
Should be taken with food.
Contraindications
Sinus bradycardia & SA heart block, evidence or history of thyroid dysfunction. Avoid in patients w/ severe resp failure. High dosage may lead to severe bradycardia & to conduction disturbances w/ appearance of idioventricular rhythm in elderly or during digitalis therapy. Pregnancy & lactation.
Patients w/ heart failure. Not to be used in patients w/ galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption. Intended only for patients w/ life-threatening arrhythmias. Monitor liver function before treatment & periodically thereafter.
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