Reduces LDL-cholesterol, apolipoprotein B & triglycerides; & increases HDL-cholesterol in the treatment of hyperlipidaemias including hypercholesterolaemias & combined (mixed) hyperlipidaemias (type IIa or IIb hyperlipoproteinaemias), hypertriglyceridaemia & dysbetalipoproteinaemia. Adjunctive therapy in patients w/ homozygous familial hypercholesterolaemia who have some LDL-receptor function.
Discontinue use if marked or persistent increased serum aminotransferase conc & creatine phosphokinase occur or if myopathy is diagnosed. Patients at risk of rhabdomyolysis particularly those who are taking drugs that increase plasma conc of statin. Severe renal impairment.
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