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Pharmacology: Diclofenac Spray is an anti-inflammatory and analgesic preparation designed for external application.
Pharmacokinetics: When Diclofenac Spray is applied locally, the active substance is absorbed through the skin. In healthy volunteers approximately 6% of the dose applied is absorbed when determined by urinary excretion of Diclofenac and its hydroxylated metabolites. Findings in patients confirm that Diclofenac penetrates inflamed areas following local application of Diclofenac Spray. Synovial fluid and tissue levels of Diclofenac are higher than those detected in plasma.
