Abixa Drug Interactions

Due to the pharmacological effects and the mechanism of action of memantine the following interactions may occur: The mode of action suggests that the effects of L-dopa, dopaminergic agonists and anticholinergics may be enhanced by concomitant treatment with NMDA-antagonists eg, memantine. The effects of barbiturates and neuroleptics may be reduced. Concomitant administration of memantine with the antispasmodic agents, dantrolene or baclofen, can modify their effects and a dosage adjustment may be necessary.
Concomitant use of memantine and amantadine should be avoided, owing to the risk of pharmacotoxic psychosis. Both compounds are chemically related NMDA-antagonists. The same may be true for ketamine and dextromethorphan (see Precautions). There is 1 published case report on a possible risk also for the combination of memantine and phenytoin.
Other drugs eg, cimetidine, ranitidine, procainamide, quinidine, quinine and nicotine that use the same renal cationic transport system as amantadine may also possibly interact with memantine leading to a potential risk of increased plasma levels.
There may be a possibility of slightly reduced serum level of hydrochlorothiazide (HCTZ) when memantine is co-administered with HCTZ or any combination with HCTZ.
Memantine did not inhibit CYP1A2, 2A6, 2C9, 2D6, 2E1, 3A, flavin containing monooxygenase, epoxide hydrolase and sulphation in vitro.
Incompatibilities: Not applicable.