Zithracin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Warnings Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Azithromycin

Indications/Uses

Lower resp tract infections including bronchitis & pneumonia; skin & soft tissue infections; acute otitis media; URTI including sinusitis & pharyngitis/tonsillitis. Uncomplicated genital infections due to Chlamydia trachomatis & non-multiresistant Neisseria gonorrhoeae. Chancroid due to Haemophilus ducreyi.

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Dosage/Direction for Use

Adult & elderly STD caused by Chlamydia trachomatis, Haemophilus ducreyi & susceptible Neisseria gonorrhoeae 1,000 mg as single dose. Other indications 500 mg daily for 3 days or 500 mg on day 1, then 250 mg on days 2-5. Childn Total dose: 30 mg/kg given as 10 mg/kg single daily dose for 3 days or 10 mg/kg daily over 5 days as 10 mg/kg on day 1, then 5 mg/kg on days 2-5. Max: 1,500 mg. Acute otitis media Alternative dosing: 30 mg/kg single dose. Ped Strep pharyngitis 10 or 20 mg/kg as single dose for 3 days. Max: Not to exceed 500 mg daily.

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Overdosage

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Administration

May be taken with or without food.

Contraindications

Hypersensitivity to azithromycin, erythromycin, other macrolides or ketolides.

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Warnings

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Special Precautions

Discontinue use if severe cutaneous adverse reactions, signs & symptoms of hepatitis occur. Unsuitable for phenylketonurics. Superinfection; Clostridium difficile-associated diarrhea; congenital or documented QT prolongation; electrolyte disturbance; clinically relevant bradycardia, cardiac arrhythmia or insufficiency; myasthenia gravis. Not to be co-administered w/ ergot derivatives. Concomitant use w/ drugs prolonging QT interval eg, class IA & III antiarrhythmics, antipsychotics, antidepressants, fluoroquinolones. Significant hepatic disease; severe renal impairment (GFR <10 mL/min). Pregnancy & lactation. Infantile hypertrophic pyloric stenosis in neonates treated up to 42 days of life. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Transient episodes of mild neutropenia; hearing impairment; nausea, vomiting, diarrhea, loose stools, abdominal discomfort, flatulence; abnormal liver function; local pain & inflammation at infusion site.

Drug Interactions

Reduced peak serum conc w/ antacids. Increased serum levels of P-gp substrates eg, digoxin, colchicine. Possible interaction w/ ergot derivatives. Increased conc of phosphorylated zidovudine. Rhabdomyolysis w/ atorvastatin. Elevated cyclosporin C_max & AUC. Monitor prothrombin time w/ coumarin-type oral anticoagulants.

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Storage

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Description

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Action

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MIMS Class

Macrolides

ATC Classification

J01FA10 - azithromycin ; Belongs to the class of macrolides. Used in the systemic treatment of infections.

Regulatory Classification

Presentation/Packing

Form

Zithracin powd for oral susp 200 mg/5 mL

Packing/Price

(fruity flavour) 20 mL x 1's

Zithracin

azithromycin

Manufacturer:

Y.S.P. Industries

Distributor:

Y.S.P. Industries