Zithracin Dosage/Direction for Use

Azithromycin Oral: Oral azithromycin should be administered as a single daily dose. The period of dosing with regard to infection is given as follows.
Azithromycin powder for oral suspension can be taken with or without food.
In Adults: For the treatment of sexually transmitted diseases caused by Chlamydia trachomatis and Haemophilus ducreyi, or susceptible Neisseria gonorrhoeae, the dose is 1000 mg as a single oral dose.
For patients who are allergic to penicillin and/or cephalosporins, prescribers should consult local treatment guidelines.
For all other indications in which the oral formulation is administered, the total dosage of 1500 mg should be given as 500 mg daily for 3 days. As an alternative, the same total dose can be given over 5 days with 500 mg given on Day 1, then 250 mg daily on Days 2 to 5.
In Children: The maximum recommended total dose for any treatment is 1500 mg for children. In general, the total dose in children is 30 mg/kg. Treatment for pediatric streptococcal pharyngitis should be dosed at a different regimen (see as follows). The total dose of 30 mg/kg should be given as a single daily dose of 10 mg/kg for 3 days, or given over 5 days with a single daily dose of 10 mg/kg on Day 1, then 5 mg/kg on Days 2-5. As an alternative to the previously mentioned dosing, treatment for children with acute otitis media can be given as a single dose of 30 mg/kg.
For pediatric streptococcal pharyngitis, azithromycin given as a single dose of 10 mg/kg or 20 mg/kg for 3 days has been shown to be effective; however, a daily dose of 500 mg must not be exceeded. In clinical trials comparing these two dosage regimens, similar clinical efficacy was observed, but greater bacteriologic eradication was evident at the 20 mg/kg/day dose. However, penicillin is the usual drug of choice for the treatment of Streptococcus pyogenes pharyngitis, including prophylaxis of rheumatic fever.
For children weighing less than 15 kg, azithromycin suspension should be measured as closely as possible. For children weighing 15 kg or more, azithromycin suspension should be administered according to the guide provided as follows. (See table.)

Click on icon to see table/diagram/image

Special populations: In the Elderly: The same dosage as in adult patients is used in the elderly. Elderly patients may be more susceptible to the development of torsades de pointes arrhythmia than younger patients.
In Patients with Renal Impairment: No dose adjustment is necessary in patients with GFR 10-80 mL/min. Caution should be exercised when azithromycin is administered to patients with GFR <10 mL/min.
In Patients with Hepatic Impairment: The same dosage as in patients with normal hepatic function may be used in patients with mild to moderate hepatic impairment.
Route of Administration(s): Oral azithromycin should be administered as a single daily dose. Azithromycin oral suspension can be taken with or without food.