Zinobial Mechanism of Action

Combination of zinc and probiotics could improve the treatment and reduce the complications of diarrheal issues. Zinc is one of the micronutrients that is very effective in human health, especially in children. Zinc therapy improves the absorption of water and electrolytes from the intestine, stimulates epithelialization, increases the level of intestinal enzymes and enhances the immune response, resulting in rapid clearance of diarrhea. Zinc also has a marked effect on T cell function and its supplementation improves immunity. Thus, it may also reduce the severity of diarrhea. Zinc supplementation during acute diarrhea in children is currently recommended by the World Health Organization and UNICEF.
Probiotics are vital microorganisms which support the intestinal flora and reduce bacterial invasion of the intestinal wall. They prevent the growth of pathogens, enhance the production of antimicrobial substances and changes in the acidity of the intestinal environment, thereby minimizing the chances of infection by producing short-chain fatty acids (SCFAs). The SCFAs that are absorbed into bloodstream also promotes fluid absorption. Probiotics have also been evaluated for the control of rotaviral diarrhea in children. They are important in controlling and reducing the symptoms of acute gastroenteritis, poisoning, irritable bowel syndrome (IBS), bowel disease caused by Clostridium difficile and food allergies.