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Cases of overdose of Xenpozyme have been reported in paediatric patients during dose escalation. Some of these patients experienced serious adverse reactions within 24 hours of treatment initiation, including death. The main clinical findings included respiratory failure, hypotension, marked elevations in liver function tests, and gastrointestinal bleeding.
There is no known specific antidote for Xenpozyme overdose. In the event of overdose, the infusion should be stopped immediately, and the patient should be monitored closely in a hospital setting for the development of IARs including acute phase reactions. For the management of adverse reactions, see Precautions and Adverse Reactions.
