Vibee Mechanism of Action

Pharmacology: Pharmacodynamics: VIBEE contains essential vitamin B complex, including vitamin B₁₂.
Vitamin B₁ (Thiamine mononitrate) is required for carbohydrate metabolism.
Vitamin B₆ (Pyridoxine Hydrochloride) is required for protein, fat and carbohydrate metabolism.
Vitamin B₁₂ (Cyanocobalamin) is associated with fat and carbohydrate metabolism and protein synthesis.
Thiamine combines with adenosine triphosphate (ATP) to form thiamine pyrophosphate, which acts as a coenzyme in carbohydrate metabolism.
Pyridoxine is converted to the active form. Pyridoxal phosphate, by the enzyme pyridoxal kinase. The active form acts as a coenzyme in the metabolism of protein, carbohydrate and fat.
Vitamin B₁₂ (Cyanocobalamin) can be converted to coenzyme B₁₂ in tissues and such involves the synthesis of protein.
Moreover it is associated with fat and carbohydrate metabolism.
VIBEE contains vitamin B₁, vitamin B₆ and vitamin B₁₂ which are essential neurotropic vitamins.
Pharmacokinetics: Relevant Pharmacokinetic data: Vitamin B₁ (Thiamine Mononitrate): Absorption: It is readily absorbed following oral administration. The oral absorption is limited to about 4-8 mg. GI absorption of thiamine is decreased in alcoholics and in patients with cirrhosis or malabsorption.
Distribution: It is widely distributed into body tissues. Body stores of thiamine have been estimated to about 30 mg with about a 1 mg dally turnover.
Elimination: Thiamine is metabolized in the liver. Little or no unchanged thiamine is excreted in urine following administration of physiologic doses.
Vitamin B₆ (Pyridoxine Hydrochloride): Absorption: It is readily absorbed following oral administration. Normal serum concentrations of pyridoxine are 30-80 mg/mL.
Distribution: It is stored mainly in the liver with lesser amount in muscle and brain. The total body store amount of vitamin B₆ is estimated to be 16-27 mg. It crosses the placenta.
Elimination: In the liver, pyridoxal is oxidized to 4-pyridoxic acid which is excreted in urine.
Vitamin B₁₂ (Cyanocobalamin): Absorption: Cyanocobalamin is irregularly absorbed from distal small intestine. Intrinsic factor (IF), a glycoprotein secreted by the gastric mucosa, is necessary for active absorption of vitamin B₁₂ from gastrointestinal tract. The IF transport mechanism is saturated by 1.5-3 mcg of the vitamin. Additional amounts of the vitamin may be absorbed independent of IF by passive diffusion through intestinal wall.
Distribution: Cyanocobalamin is extensively bound to specific plasma proteins called transcobalamins. A small amount may be free or loosely bound. It is distributed into liver, bone marrow and other tissues including placenta. Total body stores are estimated to range 1-11 mg, with an average of 5 mg, and mainly stored in the liver.
Elimination: Cyanocobalamin is excreted in bile, part of a dose is excreted in urine, most of it in the first 8 hours. The daily turnover rate of the vitamin is 0.05-0.2% of the total body stores.