UNIREN Spray 1% w/w should be applied only to intact, non-diseased skin and not to skin wounds or open injuries. It should not be used with occlusion. It should not be allowed to come into contact with the eyes or mucous membranes, and should never be taken by mouth.
Patients with a history of, or active, peptic ulceration. Some possibility of gastro-intestinal bleeding in those with a significant history of this condition has been reported in isolated cases.
Like other drugs that inhibit prostaglandin synthetase activity, Diclofenac and other NSAIDs can precipitate bronchospasm if administered to patients suffering from or with a previous history of asthma or allergic disease. Discontinue if rash develops.
*Severe cutaneous reactions including Stevens-Johnson syndrome and toxic epidermal necrolysis (Lyell's syndrome), have been reported with Diclofenac sodium. Patients treated with Diclofenac sodium should be closely monitored for signs of hypersensitivity reactions. Discontinue Diclofenac sodium immediately if rash occurs.
Adverse effects: Dermatological: Occasional rashes or skin eruptions. Cases of hair loss, bullous eruptions, erythema multiforme, Stevens-Johnson syndrome, toxic epidermal necrolysis (Lyell's syndrome), and photosensitivity reactions have been reported.