The following interactions have been noted: Central Nervous System (CNS) depressants (alcohol, sedatives, opioid analgesics, hypnotics); May cause an increase in sedation effects monoamine oxidase inhibitors (MAOIs) and tricyclic antidepressants (TCAs); May prolong and intensify the anticholinergic and CNS depressive effects other sympathomimetic agents, such as decongestants, appetite suppressants and amphetamine-like pyschostimulants; May cause an increase in blood pressure and additive effects methyldopa and β-blockers; May cause an increase in blood pressure.
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