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Contraindicated combinations: Antiemetic neuroleptics: Reciprocal antagonism between the dopaminergic agent agonist and the neuroleptics.
Use an anti-emetic without extrapyramidal effects.
Inadvisable combinations: Antipsychotic neuroleptics (except clozapine): Reciprocal antagonism between the dopaminergic agent and the neuroleptics.
The dopaminergic agent can provoke or aggravate psychotic disorders. If a neuroleptic treatment is required in parkinsonian patients treated with dopaminergic agents, the latter must be gradually reduced until withdrawal (the sudden withdrawal of dopaminergic agents can expose to a "neuroleptic malignant neuroleptic syndrome" risk).
Tetrabenazine: Reciprocal antagonism between the dopaminergic agent and tetrabenazine.
Alcohol consumption: Alcohol increases the sedative effect of piribedil.
Impaired vigilance may make driving vehicles and the use of machinery dangerous.
Combinations to be taken into account: Other sedatives: Increase in central depression.
The impairment of alertness could make driving and using machines dangerous.
