Tazemetostat is used to treat cancer of the soft tissue, which usually affects the arms, hands, legs, or feet. It is used for individuals whose cancer has grown beyond the body part where it started growing or has spread to other parts of the body and cannot be removed by surgery.
This medicine may also be used to treat a type of cancer that starts from white blood cells called lymphocytes. It is used for those who have failed previous therapy or whose disease has come back.
Take Tazemetostat exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
You may take this medicine with or without food. Try to take it at the same time each day.
Swallow the tablet whole with a glass of water. Do not divide, chew, or crush the tablet.
If you vomit after taking Tazemetostat, do not repeat the dose. Take the next dose at your normal scheduled time.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on your response to the medication.
Tazemetostat must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
If you miss a dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Let your doctor know if you are pregnant.
Both men and women must use proven birth control methods during Tazemetostat therapy and for 6 months (in women) or 3 months (in men) after stopping the treatment. Effective non-hormonal birth control methods (e.g. condoms) are recommended in women because birth control pills and other hormonal forms of birth control methods may not be effective if used during treatment. You may wish to discuss reliable methods of birth control with your doctor.
Inform your doctor if you are breastfeeding. Avoid breastfeeding during treatment and for 1 week after stopping the treatment.
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Pregnancy tests must be done before treatment to know if this medicine is suited for you to take.
- Routine blood tests may be done while you are being treated with this medicine. Your doctor will advise you about how often you need to have these tests.
- Regular monitoring of signs or symptoms of new cancers may also be needed.
Tazemetostat may cause any of the following side effects: headache, nausea, vomiting, constipation, diarrhoea, decreased appetite, cough, muscle pain, cold-like symptoms, and hair loss.
This medicine may cause the level of your red blood cells, white blood cells and platelets to drop.
Red blood cells carry oxygen around your body. A fall in the level of red blood cells may make you feel tired and worn out.
White blood cells help your body to fight infections. A fall in the level of your white blood cells may put you at higher risk for infections, such as coughs, colds and flu, which may lead to more serious infections. Avoid crowded places and people who are sick. Inform your doctor if you have a fever, cough, or flu that does not go away.
Platelets help your blood to clot when there is a cut in the skin. A fall in the level of your platelets may put you at risk of bleeding more than usual. Do not take part in activities where you may fall or get injured, such as contact sports. Inform your doctor if you get any unusual bruising (large bruises or several bruises, especially if the bruises appeared on their own) or bleeding that takes a long time to stop (for example, too much bleeding when you floss or brush your teeth).
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Inform your doctor and pharmacist if you are taking any of these medicines:
- fluconazole (medicine to treat fungal infection)
- birth control pills
- midazolam (medicine for sleep disorder)
- St. John's wort (herbal medicine)
This list does not include all medicines that may interact with Tazemetostat.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Avoid excessive consumption of grapefruit or grapefruit juice (more than 1 litre a day).
Store in a cool, dry place away from the reach of children.
Medicines must not be used past the expiry date.
As Tazemetostat is a cancer medicine, always return any unused or expired tablets to the clinic, hospital, or pharmacy for disposal. Do not throw it away in the household waste.
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