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Oral administration.
Gout: The recommended adult dosage is 250 mg twice a day for one week, followed by 500 mg twice a day thereafter. The daily dosage may be increased by 0.5 g increments every 4 weeks within tolerance (and usually not above 2 g per day) if symptoms of gouty arthritis are not controlled or the 24 hour uric acid excretion is not above 700 mg.
A liberal fluid intake is recommended as well as sufficient sodium bicarbonate (3 to 7.5 g daily) or potassium citrate (7.5 g daily) to maintain an alkaline urine. When acute attacks have absent for 6 months or more and serum urate levels remain within normal limits, the daily dosage may be decreased by 500 mg every 6 months.
Probenecid and Penicillin Therapy: Adults: The recommended dosage is 2 g daily in divided doses.
Children 2-14 years: Initial dose 25 mg/kg body weight daily.
Maintenance: 40 mg/kg body weight daily, divided into 4 doses.
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