Sign Out
Pharmacology: Furosemide (Soupinchon) is a potent diuretic with a rapid action. It inhibits the reabsorption of electrolytes in the ascending limb of the loop of Henle and also in the distal renal tubules. It may also have a direct effect in the proximal tubules. Excretion of sodium, potassium and chloride ions is increased and water excretion enhanced.
Summary of pharmacodynamics and pharmacokinetics: Absorption: Furosemide (Suopinchon) is readily absorbed from injection site. The onset of diuresis following intravenous administration is within 5 minutes and somewhat later intramuscular administration.
Blood concentration: The peak effect occurs within the first half hour. The duration of diuretic effects is approximately 2 hours.
Half-life: Peak plasma concentrations increase with increasing dose but times-to-peak do not differ among doses. The terminal half-life of is approximately 2 hours.
Protein binding: Plasma concentrations ranging from 1 to 400 mcg/ml are 91 to 99% bound in healthy individuals. The unbound fraction averages 2.3 to 4.1% at therapeutic concentration.
Excretion: It is mainly excreted in the urine; largely unchanged variable amounts are also excreted in the bile, non-renal elimination being considerably increased in renal failure.
