Streptokinase Karma Contraindications

Hypersensitivity to the active substance or to any of the excipients.
Contraindications to treatment with Streptokinase, because of the increased risk of haemorrhage under thrombolytic therapy, include: existing or recent internal haemorrhage; all forms of reduced blood coagulability, in particular spontaneous fibrinolysis and extensive clotting disorders; recent cerebrovascular accident, intracranial or intraspinal surgery; intracranial neoplasm; recent head trauma; arteriovenous malformation or aneurysm; known neoplasm with risk of haemorrhage; acute pancreatitis; uncontrollable hypertension with systolic values over 200 mm Hg and/or diastolic values; over 100 mm Hg or hypertensive retinal changes Grades III/IV; recent implantation of a vessel prosthesis; simultaneous or recent treatment with oral anticoagulants (INR >1.3); severe liver or kidney damage; endocarditis or pericarditis. Isolated cases of pericarditis, misdiagnosed as acute myocardial infarction and treated with streptokinase, have resulted in pericardial effusions including tamponade; known haemorrhagic diathesis; recent major operations (6th to 10th post-operative day, depending on the extent of the procedure); invasive operations, e.g. recent organ biopsy, long-term (traumatic) closed chest cardiac massage.