Sodium citrate: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Oral
Cystitis

Adult: For relief of symptoms in women: As 4 g sachet for oral solution: 1 sachet (4 g) tid.

Parenteral
Anticoagulant

Adult: For use with automated apheresis devices: As 4% trisodium citrate dihydrate solution: Recommended dose is determined by the apheresis device. Refer to local or specific product guidelines.

What are the brands available for Sodium citrate in Malaysia?

CCM Sterile Sodium Citrate

Administration

Sodium citrate Should be taken with food. Swallow whole.

Reconstitution

Sachet for oral solution: Dissolve sachet contents in 125 mL of water.

Contraindications

Oral: Diabetes, heart disease, hypertension, history of renal disease or patients who are on low salt diet.

Special Precautions

Patient with shock or hypoperfusion. Hepatic impairment. Pregnancy and lactation.

Adverse Reactions

Cardiac disorders: Arrhythmia, chest pressure.
Gastrointestinal disorders: Stomach cramps.
Renal and urinary disorders: Mild diuresis (oral).
Vascular disorders: Hypotension.

Monitoring Parameters

When used as anticoagulant: Monitor serum electrolytes, acid-base balance and anion gap.

Overdosage

Symptoms: Gastrointestinal discomfort, diarrhoea, sodium overloading and hyperosmolality. Management: Symptomatic treatment. Correct fluid and electrolyte balance.

Drug Interactions

May reduce the plasma levels of lithium.

Action

Description:
Mechanism of Action: Sodium citrate is metabolised to bicarbonate which increases free bicarbonate ions excretion, resulting in increased urinary pH. Elevation in urinary pH enhances the solubility of cystine in the urine and the ionisation of uric acid to more soluble urate ion. Additionally, it acts as an anticoagulant by chelating free ionised calcium in the blood, thus making it unavailable for use in the coagulation system.
Pharmacokinetics:
Excretion: Via urine.

Chemical Structure

Storage

Store below 30°C.

MIMS Class

Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics) / Other Drugs Acting on the Genito-Urinary System

References

Anticoagulant Sodium Citrate Solution (Baxter Healthcare Corporation). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/04/2025.

Anticoagulant Sodium Citrate. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 11/04/2025.

Brayfield A, Cadart C (eds). Bicarbonate. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/04/2025.

Joint Formulary Committee. Sodium Citrate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 08/04/2025.

Sodium Citrate 4% w/v Anticoagulant Injection, Solution (Terumo BCT, Ltd). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 08/04/2025.

Urobase Sachet 4 g for Oral Solution (AV Manufacturing Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 08/04/2025.

Disclaimer: This information is independently developed by MIMS based on Sodium citrate from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com