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RE-B FORTE is a combination of the 3 essential neurotropic vitamin B group.
Pharmacology: Thiamine is involved in carbohydrate metabolism and in nerve transmission. Thiamine combines with adenosine triphosphate (ATP) to form a coenzyme, thiamine pyrophosphate (thiamine diphosphate, cocarboxylase), which is necessary for carbohydrate metabolism.
Pyridoxine is involved in amino acid metabolism and in protein metabolism. Pyridoxine is converted in erythrocytes to pyridoxal phosphate and to a lesser extent pyridoxamine phosphate which acts as coenzymes for various metabolic functions affecting protein, carbohydrate and lipid utilization. Pyridoxine is involved in conversion of tryptophan to niacin or serotonin, breakdown of glycogen to glucose-1-phosphate, conversion of oxalate to glycine, synthesis of gamma aminobutyric acid (GABA) within the CNS, and synthesis of heme.
Cyanocobalamin influences hematopoiesis. It is involved in formation and metabolism of purities and pyrimidines and in the synthesis of nucleoproteins. Vitamin B12 acts as coenzyme for various metabolic functions, including fat and carbohydrate metabolism and protein synthesis. It is necessary for growth, cell replication, hematopoiesis and nucleoprotein and myelin synthesis, largely due to its effects on metabolism of methionine, folic acid and malonic acid.
Pharmacokinetics: Thiamine is absorbed from the gastrointestinal tract and is widely distributed to most body tissues. It is not stored in the body and amounts in excess of the body's requirements are excreted in urine as uncharged thiamine or as its metabolite, pyrimidine. Pyridoxine is absorbed from the gastrointestinal tract and is converted to the active from: Pyridoxal phosphate. Pyridoxal phosphate is transformed to pyridoxic acid and excreted in the urine. Cyanocobalamin is absorbed from the gastrointestinal tract. In the blood, it is bound to plasma proteins and stored in the liver. It is excreted in the bile and undergoes some enterohepatic recycling, also excreted in urine.
