Sign Out
Allergic conditions
Adult: As promethazine hydrochloride: 25-50 mg via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. If continued treatment is necessary, switch to oral route as soon as possible. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Intramuscular, Intravenous
Adjunct to pre- or post-operative sedation
Adult: As an adjunct to analgesics (at a reduced dose): As promethazine hydrochloride: 25-50 mg via deep IM inj (preferred), via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As an adjunct to analgesics or barbiturates (at a reduced dose): As promethazine hydrochloride: ≥2 years 0.5-1.1 mg/kg. Max dose: 12.5-25 mg. Dose may be given via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Use the lowest effective dose. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As an adjunct to analgesics or barbiturates (at a reduced dose): As promethazine hydrochloride: ≥2 years 0.5-1.1 mg/kg. Max dose: 12.5-25 mg. Dose may be given via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Use the lowest effective dose. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Intramuscular, Intravenous
Obstetric sedation
Adult: As promethazine hydrochloride: Early stages of labour: 50 mg. Established labour: In combination with an opioid analgesic (at a reduced dose): 25-75 mg, may be repeated once or twice at 4-hour intervals during labour. Max total dose: 100 mg during a 24-hour period of labour. Doses are given via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Intramuscular, Intravenous
Sedation
Adult: As promethazine hydrochloride: 25-50 mg via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: 5-10 years 6.25-12.5 mg via deep IM inj. Use the lowest effective dose.
Child: As promethazine hydrochloride: 5-10 years 6.25-12.5 mg via deep IM inj. Use the lowest effective dose.
Intramuscular, Intravenous
Nausea and vomiting
Adult: As promethazine hydrochloride: 12.5-25 mg, repeated at intervals of not less than 4 hours if needed, given via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: ≥2 years 0.25-0.5 mg/kg 4-6 hourly as needed. Dose may be given via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Use the lowest effective dose. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and individual products (refer to specific product guidelines).
Child: As promethazine hydrochloride: ≥2 years 0.25-0.5 mg/kg 4-6 hourly as needed. Dose may be given via deep IM inj (preferred), or via slow IV inj or injected into the tubing of freely running infusion in a concentration of not more than 25 mg/mL (usually diluted to 2.5 mg/mL). Max rate of infusion: 25 mg/min. Use the lowest effective dose. Dosage, IV dilution, and IV infusion rate recommendations may vary among countries and individual products (refer to specific product guidelines).
Oral
Motion sickness
Adult: As promethazine hydrochloride: 25 mg given the night before travelling, may be repeated after 6-8 hours if necessary. Alternatively, 25 mg given 30-60 minutes before travelling, may be repeated 8-12 hours later if needed; may administer 25 mg bid on subsequent travel days if necessary. As promethazine teoclate: Prophylaxis: 25 mg given the night before travelling (for long journeys) or 1-2 hours before travelling (for short journeys). Treatment: 25 mg as soon as possible and repeated in the same evening, followed by a 3rd dose the next evening. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: 2-5 years 5 mg given the night before the journey and repeated after 6-8 hours if necessary; 6-12 years 10 mg given the night before the journey and repeated after 6-8 hours if necessary. As promethazine teoclate: 5-10 years Prophylaxis: 12.5 mg given the night before travelling (for long journeys) or 1-2 hours before travelling (for short journeys). Treatment: 12.5 mg as soon as possible and repeated in the evening, followed by a 3rd dose the next evening; >10 years Same as adult dose. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: 2-5 years 5 mg given the night before the journey and repeated after 6-8 hours if necessary; 6-12 years 10 mg given the night before the journey and repeated after 6-8 hours if necessary. As promethazine teoclate: 5-10 years Prophylaxis: 12.5 mg given the night before travelling (for long journeys) or 1-2 hours before travelling (for short journeys). Treatment: 12.5 mg as soon as possible and repeated in the evening, followed by a 3rd dose the next evening; >10 years Same as adult dose. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Allergic conditions
Adult: As promethazine hydrochloride: 25 mg at night, may be increased to 25 mg bid if necessary. Alternatively, 10-20 mg 2-3 times daily. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: 2-5 years 5-15 mg as a single dose at night or 5 mg bid; 6-12 years 10-25 mg as a single dose at night or 5-10 mg bid. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: 2-5 years 5-15 mg as a single dose at night or 5 mg bid; 6-12 years 10-25 mg as a single dose at night or 5-10 mg bid. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Nausea and vomiting
Adult: Due to labyrinthitis or other causes: As promethazine teoclate: 25 mg at night, may be increased to 50 mg or 75 mg at night or to 25 mg 2 or 3 times daily if necessary. Max: 100 mg daily. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: Due to labyrinthitis or other causes: As promethazine teoclate: 5-10 years 12.5-37.5 mg daily; >10 years Same as adult dose. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Child: Due to labyrinthitis or other causes: As promethazine teoclate: 5-10 years 12.5-37.5 mg daily; >10 years Same as adult dose. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Oral
Insomnia
Adult: For short-term management: As promethazine hydrochloride: 20-50 mg at night.
Oral
Nausea and vomiting
Adult: As promethazine hydrochloride: 12.5-25 mg 4-6 hourly as needed. Max: 100 mg daily. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: 2-5 years 5 mg 4-6 hourly to a Max daily dose of 15 mg; 6-12 years 10 mg 4-6 hourly to a Max daily dose of 25 mg. Alternative dosing based on US recommendation: ≥2 years 0.25-0.5 mg/kg (Max: 25 mg/dose) 4-6 hourly as needed; in some patients, doses up to 1.1 mg/kg may be necessary. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Child: As promethazine hydrochloride: 2-5 years 5 mg 4-6 hourly to a Max daily dose of 15 mg; 6-12 years 10 mg 4-6 hourly to a Max daily dose of 25 mg. Alternative dosing based on US recommendation: ≥2 years 0.25-0.5 mg/kg (Max: 25 mg/dose) 4-6 hourly as needed; in some patients, doses up to 1.1 mg/kg may be necessary. Use the lowest effective dose. Dosage recommendations and approved age groups may vary among countries and between individual products (refer to local or specific product guidelines).
Rectal
Motion sickness
Adult: As promethazine hydrochloride supp: Initially, 25 mg 30-60 minutes before travelling, may be repeated 8-12 hours later if needed. On subsequent travel days, 25 mg bid may be given if needed.
Rectal
Sedation
Adult: For night-time or pre- or post-operative sedation: As promethazine hydrochloride supp: 25-50 mg. Treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Rectal
Allergic conditions
Adult: As promethazine hydrochloride supp: 25 mg at bedtime. Alternatively, 12.5 mg before meals and at bedtime, if necessary. Dosage and treatment recommendations may vary among countries and between individual products (refer to local or specific product guidelines).
Rectal
Nausea and vomiting
Adult: As promethazine hydrochloride supp: 12.5-25 mg 4-6 hourly as needed.
Continue with Google