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Orange flavour: The analgesic of choice in pregnant patients. Paracetamol is considered to be safe in normal therapeutic doses for short-term use as a minor analgesic/antipyretic in pregnancy, although it crosses placenta.
Excreted in breast milk. Maternal ingestion of paracetamol in normal therapeutic doses does not appear to present a risk to the nursing infant.
Pineapple flavour: Fertility: There is no information relating to the effects of this medicine on fertility.
Pregnancy: A large amount of data on pregnant women indicates neither malformative nor feto/neonatal toxicity. Epidemiological studies on neurodevelopment in children exposed to paracetamol in utero show inconclusive results. If clinically needed, paracetamol can be used during pregnancy, however, it should be used at the lowest possible time and at the lowest possible frequency.
When given to the mother in therapeutic doses (1 g single dose), paracetamol crosses the placenta into foetal circulation as early as 30 minutes after ingestion and is metabolised in the foetus by conjugation with sulfate and increasingly with glutathione.
Breast-feeding: Paracetamol is excreted in breast milk but not in clinically significant quantities. Available published data do not contraindicate breast-feeding.
Strawberry flavour: Pharmaceutical studies in 12 nursing mothers given a single dose of Paracetamol suggested that maternal ingestion of Paracetamol in usual therapeutic doses does not appear to present a risk to nursing infants.
Paracetamol metabolites were found in the neonate following maternal overdose at 36 weeks. The baby was delivered by Caesarean section and did not suffer liver damage; the mother was treated with Acetylcysteine.
