Discontinue use at 1st appearance of skin rash, mucosal lesions or any other signs of hypersensitivity & if abnormal liver tests persist or worsen, if clinical signs & symptoms consistent w/ liver disease develop or systemic manifestations occur. Serious skin reactions eg, DRESS syndrome, exfoliative dermatitis, SJS, TEN, generalized bullous fixed drug eruption. Increased risk of serious CV thrombotic events, MI & stroke. Patients w/ prior history of or active GI disease eg, ulceration, bleeding or inflammation or other risk factors associated w/ PUD eg, alcoholism, smoking, corticosteroid therapy; new or worsening HTN; compromised cardiac function, other conditions predisposing to or worsened by fluid retention; preexisting CHF; hematologic effects. Alcohol consumption. Closely monitor BP during & throughout therapy. False +ve reaction for urinary bile using diazo tab test. Avoid concomitant use w/ non-aspirin NSAIDs including COX-2 inhibitors. Concomitant use w/ antiplatelets, SSRIs, oral anticoagulants. Not to be administered in renal impairment. Hepatic cirrhosis, nephrotic syndrome, overt renal disease. May affect fertility. Avoid use during 3rd trimester of pregnancy. Not recommended during pregnancy. Not to be used during lactation. Elderly or debilitated patients.
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