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Reports indicate that the digestion of large amounts of clarithromycin can be expected to produce gastrointestinal symptoms. One patient who had a history of bipolar disorder ingested 8 g of clarithromycin and showed altered mental status, paranoid behaviour, hypokalaemia and hypoxemia. Allergic reactions accompanying overdosage should be treated by the prompt elimination of unabsorbed drug and supportive measures.
As with other macrolides, clarithromycin plasma levels are not expected to be appreciably affected by haemodialysis or peritoneal dialysis.
