Perindopril and Amlodipine are combined in this medicine.
Perindopril + Amlodipine helps to keep your blood pressure under control.
This medicine may also be used to treat stable coronary artery disease (narrowing of the blood vessels of the heart).
Take Perindopril + Amlodipine exactly as directed by your doctor or according to the instructions on the label. Do not take more or less than instructed by your doctor.
This medicine should be taken on an empty stomach, preferably in the morning. Try to take it at the same time each day.
The dose of this medicine will be decided by your doctor. Your doctor will advise you on the treatment timeframe depending on the severity of your condition and your response to the medication.
Perindopril + Amlodipine must be taken regularly for it to be effective. Continue taking this medicine even when you feel better. Do not stop taking it unless instructed by the doctor.
Take the missed dose as soon as you remember. If it is almost time for your next dose, skip the missed dose and return to your normal dosing schedule.
DO NOT double a dose under any circumstances.
If you often forget to take your medicine, let your doctor and pharmacist know.
Alert your doctor if you have the following conditions:
- history of angioedema (swelling of the deep layers of the skin usually around the face, throat, and lips) after treatment with similar medicines such as captopril
- personal or family history of angioedema
- narrowing of one or both arteries that carry blood to the kidneys
- severe low blood pressure
- cardiogenic shock (a serious sudden condition when the heart cannot supply enough oxygen-rich blood to the brain and vital organs of the body)
- narrowing of heart valves
- unstable heart failure (weakness and inability of the heart to pump blood) after a heart attack
- undergoing dialysis or any other type of blood filtration with high-flux membranes
as Perindopril + Amlodipine may not be suitable for you.
Do not take this medicine if you are pregnant or planning to have a baby soon. If you become pregnant while being treated with Perindopril + Amlodipine, alert your doctor immediately. This medicine may cause harm to your unborn child.
Do not take Perindopril + Amlodipine with aliskiren (medicine for high blood pressure) if you have diabetes and kidney disease.
Do not take this medicine with sacubitril/valsartan (medicine for heart failure).
Inform your doctor if you have the following conditions:
- history of airway surgery
- history of angioedema unrelated to similar medicines
- other heart diseases e.g. abnormally thick heart muscle
- diabetes
- low volume of circulating fluids in the body
- primary hyperaldosteronism (a disorder where the adrenal glands produce too much of a hormone called aldosterone)
- disease of blood vessels supplying the brain
- immune system diseases affecting collagen e.g. systemic lupus erythematosus or SLE (autoimmune disease that causes inflammation of certain organs in the body)
- liver disease
- kidney disease
Let your doctor know if you are breastfeeding.
Be sure to check with your doctor or pharmacist before giving Perindopril + Amlodipine to the elderly. Elderly people may be more sensitive to the side effects.
If you are of a Black race, this medicine may be less effective. Inform your doctor if you are taking Perindopril + Amlodipine.
If you are going to have an operation, including minor surgery and dental work, inform your doctor or dentist that you are taking this medicine.
Let your doctor know if you are going to undergo other procedures or treatments such as desensitisation (treatment for an allergic reaction) to wasp or bee stings or removal of cholesterol from your blood by a machine (LDL apheresis).
Why is it important to keep my appointments with the doctor?
Keep your appointments with your doctor. Your doctor needs to monitor your condition and check your response to the medication regularly.
- Routine tests (e.g. kidney function, electrolyte levels) may be done while you are being treated with Perindopril + Amlodipine. Your doctor will advise you about how often you need to have these tests.
- Your blood pressure may fall to unsafe levels without you noticing it. Monitor your blood pressure regularly during treatment.
What lifestyle changes can I make to improve my blood pressure?
Regular exercise and eating a healthy diet will help control your blood pressure and improve your overall health. Engage in physical activity like walking for at least 30 to 60 minutes on most days of the week. If you have not exercised for a long time, start with light exercises such as slow walks. Speak to your doctor about what type of exercise would be suitable for you. Follow a healthy diet plan by eating more fruits, vegetables, whole grains and low-fat dairy products and reduce your intake of foods high in saturated fat, cholesterol and sodium. Cutting down on deep-fried foods and using less salt when cooking can kick-start your healthy diet.
If you smoke, you should try to quit. Smoking is harmful to your blood pressure, heart and overall health. Speak to your doctor or pharmacist about ways to stop your smoking habit.
Perindopril + Amlodipine may cause dizziness or weakness. If affected, do not drive or take part in any activity in which you need to be alert.
Other side effects include any of the following: headache, tiredness, muscle cramps, constipation, nausea, vomiting, diarrhoea, indigestion, changes in taste, stomach pain, ringing in the ears, rash, and joint swelling.
Some side effects may need immediate medical help. Alert your doctor quickly if you experience any of the following:
- swelling of the tongue, throat, eyelids, face or lips
- yellowing of the skin or eyes, abdominal pain, dark coloured urine, tiredness, swelling in the legs and ankles
- severe dizziness or fainting
- persistent dry cough
- muscle weakness, cramping or numbness; fast or irregular heartbeat, chest pain
Inform your doctor if any of these side effects do not go away or are severe, or if you experience other side effects.
Do not take Perindopril + Amlodipine with aliskiren (medicine for high blood pressure) if you have diabetes and kidney disease.
Do not take this medicine with sacubitril/valsartan (medicine for heart failure).
Inform your doctor and pharmacist if you are taking any of these medicines:
- water pills or medicines for water retention e.g. spironolactone, amiloride
- medicines for diabetes e.g. insulin, sitagliptin, vildagliptin
- NSAIDs (medicines for pain and inflammation) e.g. aspirin, ibuprofen
- medicines used in organ transplants or certain immune disorders e.g. everolimus, sirolimus, temsirolimus, ciclosporin
- lithium (medicine for mood disorders)
- racecadotril (medicine to treat diarrhoea)
- other medicines for high blood pressure or heart disease e.g. verapamil, diltiazem, losartan, telmisartan
- simvastatin (cholesterol-lowering medicine)
- certain medicines to treat fungal infection e.g. itraconazole, ketoconazole
- certain antibiotics e.g. erythromycin, clarithromycin, trimethoprim
- heparin (blood-thinning medicine)
- rifampicin (medicine to treat TB, a lung infection known as tuberculosis)
- potassium supplements or potassium-containing medicines
This list does not include all medicines that may interact with Perindopril + Amlodipine.
Always notify your doctor and pharmacist if you are taking any other medicines, including herbal tonics such as traditional Chinese medicines, supplements, and medicines that you buy without a prescription.
Avoid alcohol.
Avoid excessive consumption of grapefruit or grapefruit juice (more than 1 litre a day).
Cut down on your salt intake. This may help lower your blood pressure and improve your overall health. Discuss with your doctor or dietitian about ways to cut down on your salt intake.
Do not take potassium supplements or salt substitutes that contain potassium.
Avoid taking too much food that is high in potassium, such as orange juice, bananas, or prunes.
Store in a cool, dry place away from the reach of children.
Protect from light and moisture.
Medicines must not be used past the expiry date.
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