Paxlovid Contraindications

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

The information highlighted (if any) are the most recent updates for this brand.

Full Prescribing Info

Contraindications

Paxlovid is contraindicated in patients: with a history of clinically significant hypersensitivity to the active substances (nirmatrelvir/ritonavir) or to any of the excipients listed in Description; with severe hepatic impairment; with severe renal impairment.
Paxlovid is also contraindicated with medicinal products that are highly dependent on CYP3A for clearance and for which elevated plasma concentrations are associated with serious and/or life-threatening reactions. Paxlovid is also contraindicated with medicinal products that are potent CYP3A inducers, where significantly reduced plasma nirmatrelvir/ritonavir concentrations may be associated with the potential for loss of virologic response and possible resistance. Medicinal products listed in Table 8 and Table 10 (see Interactions) are a guide and not considered a comprehensive list of all possible medicinal products that may be contraindicated with Paxlovid. (See Table 8.)

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Paxlovid Contraindications

ritonavir

nirmatrelvir

Manufacturer:

Pfizer

Distributor:

Zuellig Pharma