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Parecoxib is contraindicated in: Patients with known hypersensitivity to parecoxib or to any other ingredient of the product.
Patients who have demonstrated allergic-type reactions to sulfonamides.
Patients who have experienced asthma, urticaria, or allergic-type reactions after taking acetylsalicylic acid (aspirin) or non-steroidal anti-inflammatory drugs (NSAIDs), including other cyclooxygenase-2 (COX-2) specific inhibitors.
Severe hepatic impairment (serum albumin <25 g/L or Child-Pugh score ≥10).
The third trimester of pregnancy and breast-feeding.
Active peptic ulceration or gastrointestinal (GI) bleeding.
Inflammatory bowel disease.
Congestive heart failure (NYHA II-IV).
Treatment of post-operative pain following coronary artery bypass graft (CABG) surgery.
Established ischaemic heart disease, peripheral arterial disease and/or cerebrovascular disease.
