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Overdose: The fatal dose of oxytocin has not been established. Oxytocin is subject to inactivation by proteolytic enzymes of the alimentary tract. Hence it is not absorbed from the intestine and is not likely to have toxic effects when ingested. The symptoms and consequences of overdosage are those mentioned under sections Precautions and Adverse Reactions. In addition, as a result of uterine overstimulation, placental abruption and/or amniotic fluid embolism have been reported.
Treatment: When signs or symptoms of overdosage occur during continuous IV administration of oxytocin, the infusion must be discontinued at once and oxygen should be given to the mother. In cases of water intoxication, it is essential to restrict fluid intake, promote diuresis, correct electrolyte imbalance, and control convulsions that may eventually occur. In the case of coma, a free airway should be maintained with routine measures normally employed in the nursing of the unconscious patient.
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