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Symptoms: Overdosage of ofloxacin would be expected to produce manifestations that are extensions of the adverse reactions reported with the drug, and may include nausea, vomiting, seizures, vertigo, dysgeusia and psychosis.
Treatment: If acute overdosage of ofloxacin occurs, the stomach should be emptied by inducing emesis or by gastric lavage. Supportive and symptomatic treatment should be initiated, and patient should be observed carefully while adequate hydration should be maintained. Since ofloxacin is not efficiently removed by haemodialysis or peritoneal dialysis, these procedures should not be relied on to enhance elimination of the drug from the body.
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