Discontinue use if allergic- or anaphylactic-type reactions occur. Patients w/ underlying hypercoaguable state; immunodeficiency or increased erythropoiesis eg, haemolytic anaemia; congenital or acquired deficiency; history of CHD; at risk of thromboembolic events or disseminated intravascular coagulation. Possibility of transmitting infective agents. Recommend appropriate vaccination (hepatitis A & B) for patients in regular/repeated receipt of human plasma-derived prothrombin complex products. Monitor for signs & symptoms of intravascular coagulation or thrombosis; peri- or post-op patients. Hepatic disease. Pregnancy & lactation. Neonates.