Nicardiin Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Side Effects Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Nicardipine HCl

Indications/Uses

Acute life-threatening HTN, particularly in the event of malignant arterial HTN/hypertensive encephalopathy; when short-acting β-blocker is unsuitable or in combination w/ β-blocker when β-blockade alone is ineffective in aortic dissection; when other IV antihypertensives are not recommended or contraindicated in severe pre-eclampsia. Post-op HTN.

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Dosage/Direction for Use

Adult Initially 3-5 mg/hr via continuous infusion over 15 min, may be increased by increments of 0.5-1 mg every 15 min. Maintenance dose: Reduce to 2-4 mg/hr. Max: Not to exceed 15 mg/hr. Childn Initially 0.5-5 mcg/kg/min. Maintenance dose: 1-4 mcg/kg/min. Pregnant & elderly Initially 1-5 mg/hr, may be increased or decreased by 0.5 mg/hr increments after 30 min. Max: Not to exceed 15 mg/hr.

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Overdosage

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Contraindications

Hypersensitivity. Severe aortic stenosis; compensatory HTN ie, in case of arteriovenous shunt or aortic coarctation; unstable angina; use w/in 8 days after MI. Not to be taken by patients w/ fructose intolerance.

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Special Precautions

Discontinue use or decrease dose by ½ if systemic hypotension &/or reflex tachycardia occurs. Inj site reactions. Not recommended to be administered by bolus or IV not controlled w/ electronic syringe driver or volumetric pump. CHF/pulmonary oedema; suspected coronary ischemia; portal HTN; preexisting elevated ICP; acute cerebral infarction. Combination w/ β-blockers. Concomitant use w/ Mg sulphate. History of hepatic dysfunction; hepatic & renal impairment. Not to be used in multiple pregnancies or pregnant women w/ compromised CV condition & during lactation. Childn, low birth wt & nursing infants, newborns. Elderly.

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Use In Pregnancy & Lactation

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Adverse Reactions

Headache. Dizziness; lower limb oedema, palpitations; hypotension, tachycardia; orthostatic hypotension; nausea, vomiting; flushing.

Drug Interactions

Enhanced -ve inotropic effect of β-blockers. Fatal ventricular fibrillation w/ verapamil & IV dantrolene. Risk of pulmonary oedema or excessive decreased BP w/ Mg sulphate. Decreased plasma conc by CYP3A4 inducers eg, carbamazepine, phenobarb, phenytoin, fosphenytoin, primidone, rifampicin. Increased plasma conc by CYP3A4 inhibitors eg, cimetidine, itraconazole, grapefruit juice. Increased risk of adverse reactions w/ itraconazole. Elevated plasma cyclosporine, tacrolimus or sirolimus; digoxin levels. Potentiated antihypertensive effect w/ baclofen, α-blockers, TCAs, neuroleptics, opioids, amifostine. Decreased antihypertensive effect w/ IV corticosteroids, tetracosactide. Induced potential additive or synergistic hypotensive effect w/ inhalational anaesth. Enhanced neuromuscular block w/ competitive neuromuscular blockers.

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Caution For Usage

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Storage

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Description

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Action

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MIMS Class

Calcium Antagonists

ATC Classification

C08CA04 - nicardipine ; Belongs to the class of dihydropyridine derivative selective calcium-channel blockers with mainly vascular effects. Used in the treatment of cardiovascular diseases.

Regulatory Classification

Presentation/Packing

Form

Nicardiin soln for infusion 1 mg/mL

Packing/Price

10 mL x 10 × 1's

Nicardiin

nicardipine

Manufacturer:

Nang Kuang Pharma

Distributor:

Summit

Marketer:

Pharm-D