Epilepsy Adult & paed >12 yr 900-3,600 mg daily. Initially 300 mg tds on day 1 or by titrating dose as: 300 mg once daily on day 1, 300 mg bd on day 2, 300 mg tds on day 3. Thereafter, dose may be increased in 3 equally divided doses up to max: 3,600 mg daily. Paed 3-12 yr Initially 10-15 mg/kg tds, ≥5 yr 25-35 mg/kg tds, 3 to <5 yr 40 mg/kg tds. Neuropathic pain Adult Initially 900 mg daily in 3 equally divided doses, increase if necessary up to max: 3,600 mg daily. Renal impairment CrCl ≥80 mL/min 900-3,600 mg daily, 50-79 mL/min 600-1,800 mg daily, 30-49 mL/min 300-900 mg daily, 15-29 mL/min 150-600 mg daily, <15 mL/min 150-300 mg daily. Patient undergoing hemodialysis Loading dose: 300-400 mg then 200-300 mg following each 4-hr hemodialysis.
Discontinue treatment if signs or symptoms of anaphylaxis occur. Not effective for absence seizures. Increased occurrence of accidental injury or fall; severe resp depression; compromised resp function, resp or neurological disease, drug rash w/ eosinophilia & systemic symptoms. Evaluate patients for history of drug abuse &/or psychiatric disorders. Avoid abrupt w/drawal. Concomitant use w/ opioids; CNS depressants. May affect ability to drive & use machines. Renal impairment. Women of childbearing potential should use effective contraception during treatment. Not to be used during pregnancy. Lactation. Childn <3 yr w/ epilepsy & <18 yr w/ neuropathic pain.
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