Mounjaro Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Use In Pregnancy & Lactation Adverse Reactions Drug Interactions Caution For Usage Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Tirzepatide

Indications/Uses

Adjunct to diet & exercise in adults w/ insufficiently controlled type 2 DM as monotherapy when metformin is considered inappropriate due to intolerance or contraindications, or in addition to other medicinal products for diabetes. Adjunct to reduced-calorie diet & increased physical activity for wt management including wt loss & maintenance in adults w/ initial BMI ≥30 kg/m² (obesity) or ≥27 to <30 kg/m² (overwt) in the presence of at least 1 wt-related comorbid condition (eg, HTN, dyslipidaemia, obstructive sleep apnoea, CV disease, prediabetes or type 2 DM).

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Dosage/Direction for Use

SC Initially 2.5 mg once wkly, increased to 5 mg once wkly after 4 wk. May be further increased in 2.5 mg-increments after min of 4 wk on current dose. Recommended maintenance dose: 5, 10 & 15 mg. Max dose: 15 mg once wkly.

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Overdosage

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Contraindications

Hypersensitivity.

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Special Precautions

Discontinue use if pancreatitis is suspected & not to be restarted if pancreatitis diagnosis is confirmed. Increased risk of hypoglycaemia in combination w/ insulin secretagogue or insulin. Acute pancreatitis; nausea, vomiting, diarrhoea; severe GI disease eg, severe gastroparesis; non-proliferative diabetic retinopathy requiring acute therapy, proliferative diabetic retinopathy or diabetic macular oedema. Aspiration in association w/ general anaesth or deep sedation. Contains benzyl alcohol. Ensure to avoid fluid depletion & electrolyte disturbances especially in elderly. May affect ability to drive & use machines. Severe hepatic or renal impairment & ESRD. Women of childbearing potential should use effective contraception. Discontinue use at least 1 mth before planned pregnancy & not recommended during pregnancy. Lactation. Childn <18 yr. Elderly ≥85 yr.

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Use In Pregnancy & Lactation

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Adverse Reactions

Hypoglycaemia w/ sulphonylurea or insulin; nausea, diarrhoea, vomiting, abdominal pain, constipation. Hypersensitivity reactions; hypoglycaemia w/ metformin & SGLT2i, decreased appetite; dizziness; hypotension; dyspepsia, abdominal distention, eructation, flatulence, GERD; hair loss; fatigue, inj site reactions; increased heart rate, lipase, amylase & blood calcitonin.

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Drug Interactions

Potential impact on absorption rate of concomitantly administered oral medicinal products. Monitor patients on concomitant oral medicinal products w/ narrow therapeutic index eg, warfarin, digoxin. Risk of delayed effect in oral medicinal products w/ importance for rapid onset of effect.

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Caution For Usage

For caution against possible variation of physical aspect of medicine... Click to view Mounjaro detailed prescribing information

Storage

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Description

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Action

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MIMS Class

Antidiabetic Agents / Anti-Obesity Agents

ATC Classification

A10BX16 - tirzepatide ; Belongs to the class of other blood glucose lowering drugs excluding insulins. Used in the treatment of diabetes.

Regulatory Classification

Presentation/Packing

Form

Mounjaro soln for inj (multi-dose pre-filled KwikPen) 10 mg/0.6 mL (1 dose)

Packing/Price

4 dose x 1's

Form

Mounjaro soln for inj (multi-dose pre-filled KwikPen) 12.5 mg/0.6 mL (1 dose)

Packing/Price

4 dose x 1's

Form

Mounjaro soln for inj (multi-dose pre-filled KwikPen) 15 mg/0.6 mL (1 dose)

Packing/Price

4 dose x 1's

Form

Mounjaro soln for inj (multi-dose pre-filled KwikPen) 2.5 mg/0.6 mL (1 dose)

Packing/Price

4 dose x 1's

Form

Mounjaro Soln for inj (multi-dose pre-filled KwikPen) 5 mg/0.6 mL (1 dose)

Packing/Price

4 dose x 1's

Form

Mounjaro soln for inj (multi-dose pre-filled KwikPen) 7.5 mg/0.6 mL (1 dose)

Packing/Price

4 dose x 1's

Mounjaro

tirzepatide

Manufacturer:

Eli Lilly

Distributor:

Zuellig Pharma