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Hypersensitivity to methotrexate or any excipients in the formulation.
Breast feeding.
Severe renal impairment.
Applies to patients with psoriasis or rheumatoid arthritis only: Alcoholism, alcoholic liver disease, or other chronic liver disease.
Overt or laboratory evidence of immunodeficiency syndromes.
Preexisting blood dyscrasias, such as bone marrow hypoplasia, leukopenia, thrombocytopenia, or significant anemia.
Pregnancy.
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