Metgyl Tablet Adverse Reactions

The adverse effects of metronidazole are generally dose-related . The most common are gastro-intestinal disturbances, especially nausea and an unpleasant metallic taste; nausea is sometimes accompanied by headache, anorexia, and vomiting. Diarrhoea, dry mouth, a furred tongue, glossitis, and stomatitis may also occur.
Peripheral neuropathy, usually presenting as numbness or tingling in the extremities, and epileptiform seizures are serious adverse effects on the nervous system that have been associated especially with high doses of metronidazole or prolonged treatment. Weakness, dizziness, ataxia, drowsiness, insomnia and changes in mood or mental state such as depression or confusion have also been reported.
A moderate leucopenia has been reported in some patients but the white cell count has always returned to normal before or after treatment has been completed. Skin rashes and pruritus occur occasionally and anaphylaxis has been reported rarely.
Other side effects include urethral discomfort and darkening of the urine. Raised liver enzyme values have occasionally been reported.