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Lodoz is contraindicated in patients with hypersensitivity to bisoprolol, hydrochlorothiazide, other thiazides, sulphonamides, or any of the excipients.
Bisoprolol: Bisoprolol is contraindicated in any of the following conditions: Severe asthma; Heart failure not controlled by therapy; Cardiogenic shock; Sick-sinus syndrome (including SA block); Second or third degree AV block (without pacemaker); Symptomatic bradycardia; Pheochromocytoma (except after prior alpha-receptor blocker therapy); Severe forms of Raynaud's syndrome and severe peripheral arterial occlusive disease; Metabolic acidosis; In combination with sultopride.
Hydrochlorothiazide: Hydrochlorothiazide is contraindicated in any of the following conditions: Severe renal impairment (creatinine clearance ≤30 mL/min); Severe hepatic impairment; Refractory hypokalaemia.
