AdultErectile dysfunction 10 mg once daily at least 30 min prior to anticipated sexual activity, may be increased to 20 mg once daily if 10 mg does not produce adequate effect. Benign prostatic hyperplasia 5 mg once daily. Hepatic & severe renal impairment Max recommended dose: 10 mg.
View Liberez overdosage for action to be taken in the event of an overdose.
Administration
May be taken with or without food.
Contraindications
Hypersensitivity. Not to be used in men w/ cardiac disease for whom sexual activity is inadvisable. Patients w/ MI w/in last 90 days; unstable angina or angina occurring during sexual intercourse; NYHA class ≥2 heart failure in last 6 mth; uncontrolled arrhythmias & HTN, hypotension (<90/50 mmHg); stroke w/in last 6 mth. Loss of vision in 1 eye due to non-arteritic anterior ischaemic optic neuropathy (NAION). Co-administration w/ guanylate cyclase stimulators eg, riociguat; organic nitrates.
Discontinue use if sudden vision defect, decreased or hearing loss occurs. Increased risk of acute NAION. Patients w/ pre-existing CV risk factors; undergone pelvic surgery or radical non-nerve-sparing prostatectomy. Anatomical penis deformation (eg, angulation, cavernosal fibrosis or Peyronie's disease) or conditions predisposing to priapism eg, sickle cell anaemia, multiple myeloma or leukaemia. Assess CV status prior to treatment. Not recommended for continuous daily use. Not to be taken by patients w/ galactose intolerance, total lactase deficiency or glucose-galactose malabsorption. Not to be used in combination w/ other PDE5 inhibitors or other treatments for erectile dysfunction. Not recommended in combination w/ doxazosin. Concomitant use w/ antihypertensives, α1-blockers, potent CYP3A4 inhibitors. May affect ability to drive & use machines. Severe hepatic insufficiency (Child-Pugh class C). Not to be used in women. Avoid use during pregnancy. Not to be used during lactation. 5 mg: Rule out presence of prostate carcinoma prior to initiation. Not recommended for once-daily dosing in patients w/ severe renal impairment.
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