Lantus Solostar Drug Interactions

A number of substances affect glucose metabolism and may require dose adjustment of insulin glargine.
Substances that may enhance the blood glucose-lowering agent and increase susceptibility to hypoglycaemia include oral antidiabetic agents, angiotensin-converting enzyme inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, pentoxifylline, propoxyphene, salicyclates and sulfonamide antibiotics.
Substances that may reduce the blood glucose-lowering effect include corticosteroids, danazol, diazoxide, diuretics, glucagons, isoniazid, oestrogens and progestogens, phhenothiazine derivatives, somatropin, sympathomimetic agents [eg, ephinephrine (adrenaline), salbutamol, terbutaline], thyroid hormones, atypical antipsychotic medicinal products (eg, clozapine and olanzapine) and protease inhibitors.
Beta-blockers, clonidine, lithium salts or alcohol may either potentiate or weaken the blood glucose-lowering effect of insulin. Pentamidine may cause hypoglycaemia, which may sometimes be followed by hyperglycaemia.
In addition, under the influence of sympatholytic medicinal products eg, β-blockers, clonidine, guanethidine and reserpine, the signs of adrenergic counterregulation may be reduced or absent.