Kryxana Description

Film coated, light greyish violet, round, curved with beveled edges, debossed with "RIC" on one side and "NVR" on the other side.
Tablet: 200 mg ribociclib (equivalent to 254.40 mg ribociclib succinate).
KRYXANA (ribociclib) is a kinase inhibitor.
The chemical name of ribociclib succinate is: Butanedioic acid-7-cyclopentyl-N,N-dimethyl-2-{[5-(piperazin-1-yl) pyridin-2-yl]amino}-7H-pyrrolo[2,3-d]pyrimidine-6-carboxamide (1/1).
Ribociclib succinate is a light yellow to yellowish brown crystalline powder. The molecular formula for ribociclib succinate is C₂₃H₃₀N₈O·C₄H₆O₄ and the molecular weight is 552.64 g/mol (Free base: 434.55 g/mol).
KRYXANA film-coated tablets are supplied for oral use and contain 200 mg of ribociclib free base (equivalent to 254.40 mg ribociclib succinate).
Excipients/Inactive Ingredients: The tablets also contain colloidal silicon dioxide, crospovidone, hydroxypropylcellulose, magnesium stearate and microcrystalline cellulose. The film-coating contains iron oxide black, iron oxide red, lecithin (soya), polyvinyl alcohol (partially hydrolysed), talc, titanium dioxide, and xanthan gum as inactive ingredients.