Isoconazole: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Skin fungal infections

Adult: For infections on or near the hands, in the interdigital spaces of feet, and inguinal or genital regions: As 1% cream: Apply onto the affected area(s) once daily for 2-3 weeks; may be applied up to 4 weeks for refractory cases, especially for infections in interdigital spaces. Continue therapy for at least another 2 weeks after clinical healing to prevent recurrence.

Vaginal
Vaginal mycoses

Adult: As vaginal supp: Insert 1 supp (600 mg) as a single dose at bedtime.

Contraindications

Hypersensitivity.

Special Precautions

Pregnancy and lactation.

Adverse Reactions

Significant: Hypersensitivity reactions.
Gastrointestinal disorders: Nausea (vaginal).
General disorders and administration site conditions: Application site irritation, burning sensation, pruritus, or dryness.
Nervous system disorders: Headache, dizziness (vaginal).
Reproductive system and breast disorders: Vaginal discharge (vaginal).
Skin and subcutaneous tissue disorders: Contact dermatitis, eczema, dyshidrosis.

Patient Counseling Information

Avoid contact of the topical cream with the eyes. Vaginal supp and topical application of cream to the genital region may cause damage to latex contraceptives (e.g. condoms, diaphragms), reducing the effectiveness of these products. Avoid administration of vaginal supp during menstruation.

Action

Description:
Mechanism of Action: Isoconazole, an imidazole derivative antifungal agent, is effective against dermatophytes, yeasts, yeast-like fungi, moulds and certain Gram-positive bacteria. It blocks the 14α-demethylation of lanosterol, thereby inhibiting ergosterol synthesis in fungi.
Pharmacokinetics:
Absorption: Time to peak skin concentration: 1 hour (cream).

Chemical Structure

Storage

Store below 30°C.

MIMS Class

Preparations for Vaginal Conditions / Topical Antifungals & Antiparasites

ATC Classification

D01AC05 - isoconazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.
G01AF07 - isoconazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.

References

Brayfield A, Cadart C (eds). Isoconazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 05/08/2025.

Isoconazole. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 05/08/2025.

Travogen Cream (DKSH Hong Kong Ltd.). MIMS Hong Kong. http://www.mims.com/hongkong. Accessed 05/08/2025.

Disclaimer: This information is independently developed by MIMS based on Isoconazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com