Adult: As metered-dose aerosol: 20-40 mcg 3-4 times daily; single doses of up to 80 mcg may be required in some patients. As soln for nebulisation: 250-500 mcg 3-4 times daily. Child: As metered-dose aerosol: <6 yr 20 mcg tid; 6-12 yr 20-40 mcg tid. As soln for nebulisation: <6 yr For acute asthma: 125-250 mcg, given no more often than 6 hrly up to a total dose of 1 mg. 6-12 yr For acute and chronic asthma: 250 mcg, repeated as necessary up to a total dose of 1 mg.
Nasal Rhinorrhoea associated with rhinitis
Adult: As metered-dose nasal spray: 42 mcg into each nostril 2-3 times daily, up to 84 mcg into each nostril 3-4 times daily for up to 4 days when rhinorrhoea is associated w/ common cold or up to 3 wk when associated w/ seasonal allergic rhinitis. Child: As metered-dose nasal spray: ≥12 yr 42 mcg into each nostril 2-3 times daily.
What are the brands available for Ipratropium bromide in Malaysia?
This drug may cause dizziness, accommodation disorder, mydriasis and blurred vision, if affected, do not drive or operate machinery.
Drug Interactions
Additive bronchodilatory effect w/ β-adrenergic drugs and xanthine preparations.
Action
Description: Mechanism of Action: Ipratropium bromide causes bronchodilation by blocking the action of acetylcholine at parasympathetic site in bronchial smooth muscle. It also inhibits serous and seromucous gland secretions by nasal application. Onset: Bronchodilation: W/in 15 min. Duration: 2-5 hr (oral inhalation). Pharmacokinetics: Absorption: 10-30% of a dose is deposited in the lungs while only a small amount reaches systemic circulation. Poorly absorbed from the GI tract. Bioavailability: 2% (oral inhalation); 7-28% (nasal). Distribution: Plasma protein binding: ≤9% (oral inhalation); <20% (nasal). Metabolism: Metabolised via ester hydrolysis (41%) and conjugation (36%). Excretion: Via urine and faeces. Elimination half-life: 2 hr (oral inhalation); 1.6 hr (nasal).
Chemical Structure
Ipratropium bromide Source: National Center for Biotechnology Information. PubChem Compound Summary for CID 657308, Ipratropium bromide. https://pubchem.ncbi.nlm.nih.gov/compound/Ipratropium-bromide. Accessed Oct. 24, 2023.
Storage
Aerosol/nasal spray: Store at 25°C. Protect from light or heat. Soln for nebulisation: Store between 15-30°C. Protect from light.
R03BB01 - ipratropium bromide ; Belongs to the class of other inhalants used in the treatment of obstructive airway diseases, anticholinergics. R01AX03 - ipratropium bromide ; Belongs to the class of other nasal preparations for topical use.
References
Anon. Ipratropium (Nasal). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/07/2015.Anon. Ipratropium (Oral Inhalation). Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/07/2015.Buckingham R (ed). Ipratropium Bromide. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/07/2015.Ipratropium Bromide Solution (Mylan Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/07/2015.
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