Discontinue use if allergic or anaphylactic type reactions & 1st clinical signs of CV overload (eg, headache, dyspnoea, jugular vein congestion, increased BP, raised venous pressure or pulmonary oedema) occur. Hypervolaemia or haemodilution (eg, decompensated cardiac insufficiency, HTN, oesophageal varices, pulmonary oedema, haemorrhagic diathesis, severe anaemia, renal & post-renal anuria). Possibility of transmitting infective agents. Ensure adequate hydration & substitution of other blood constituents in large vol replacement (coagulation factors, electrolytes, platelets & erythrocytes). Monitor electrolyte status & circulatory overload or hyperhydration. Patients on controlled Na diet. Not to be diluted w/ water for inj. Pregnancy.