A carmine coloured suspension with blackcurrant flavour and odour. Each 5 ml contains paracetamol 250 mg with methyl paraben 0.1% w/v and propyl paraben 0.01% w/v as preservative.
Alcohol Free.
Pharmacology: Pharmacodynamics: Paracetamol acts as an analgesic and antipyretic.
Pharmacokinetics: The mode of action of paracetamol is not known. It is thought to act as a prostaglandin synthetase inhibitor in the central nervous system but not in the peripheral tissues. This would account for its antipyretic and analgesic effect and for the possible lack of anti-inflammatory action.
Paracetamol is readily absorbed from the gastro-intestinal tract with peak plasma concentration about 30 minutes to 2 hours after ingestion. It is metabolized in the liver and excreted in the urine mainly as the glucuronide and sulphate conjugates. The elimination half-life varies from about 1 to 4 hours. Plasma protein binding is negligible at usual therapeutic concentrations.
For the relief of most mild to moderate pain including teething pain and for the symptomatic relief of fever in influenza and feverish colds. It is also a substitute for aspirin for its analgesic or antipyretic uses in patients who are allergic to aspirin or when aspirin is contra-indicated as in children and patients with peptic ulcer.
1-6 years: ½-1 teaspoon (2.5-5 ml).
7-12 years: 1-2 teaspoon (5-10 ml).
These dosages may be given undiluted 3 to 4 times daily as required.
For oral use only.
Symptoms: Vomiting, hypertension, sweating, gastrointestinal haemorrhage, liver damage, cerebral oedema and renal tubular necrosis.
Treatment: Gastric emptying (unless drowsy or unconscious) and/or lavage is recommended as soon as possible after ingestion. Diazepam may be given to control central nervous system stimulation and convulsions. A beta adrenoreceptor blocking agent may be required to control cardiac arrhythmia due to phenylpropanolamine hydrochloride. Ingestion of over 140 mg/kg or 10 g (for adults) requires prompt hospital treatment.
Antidote: To prevent or reduce liver damage, oral methionine (2.5 g) should be given after emesis and/or lavage. Additional therapy (3 further doses of 2.5 g methionine at four hourly intervals or IV cysteamine) is normally considered in the light of blood paracetamol content and the time elapsed since ingestion.
Hypersensitivity to paracetamol or any of the ingredients in the formulation.
Medication containing paracetamol should be given with care to patients with impaired kidney or liver functions and patients taking other drugs that affect the liver. Patients on anticoagulant therapy may require a reduction in dosage if on daily paracetamol medication.
This preparation contains Paracetamol.
Do not use any other Paracetamol-containing medicines at the same time.
Allergy alert: Paracetamol may cause severe skin reactions. Symptoms may include skin reddening, blisters or rash. These could be signs of a serious condition. If these reactions occur, stop use and seek medical assistance right away.
Use in pregnancy and lactation: Unknown.
Side effects are usually mild. Cutaneous hypersensitivity reactions including skin rashes, angioedema, Stevens Johnson Syndrome/Toxic Epidermal Necrolysis have been reported.
Keep container well closed after opening. Store below 30°C and protect from strong light.
Recommended shelf life: 3 years.
N02BE01 - paracetamol ; Belongs to the class of anilide preparations. Used to relieve pain and fever.
Hoemal oral susp 250 mg/5 mL
(blackcurrant flavor) 90 mL x 1's
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