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Hapacol: Alcohol reduces liver capacity to deal with paracetamol. The speed of absorption of paracetamol may be increased by metoclopramide or domperidone and absorption reduced by cholestyramine.
The anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular use of paracetamol with increased risk of bleeding; occasional doses have no significant effect.
Hapacol Junior: Associations subject to precautions for use: Oral anticoagulants: Risk of increased effect of oral anticoagulant and hemorrhagic risk if paracetamol is taken at maximum doses (4 g/d) for at least 4 days. Regular monitoring of INR. Possible adaptation of the dosage of the anticoagulant during treatment with paracetamol and after discontinuation.
Interaction with paraclinic examinations: Taking paracetamol may distort the blood glucose test by the glucose oxidase-peroxidase method in abnormally high concentrations.
Taking paracetamol can distort the dosage of blood uric acid by the phosphotungstic acid method.
