Adult w/ normal renal function (GFR ≥90 mL/min) Monotherapy & combination w/ other oral antidiabetic agents Initially 500- or 850 mg bd-tds, adjusted based on blood glucose measurements after 10-15 days. Max: 3 g daily in 3 divided doses.
Transfer from another oral antidiabetic agent Discontinue the other agent & initiate as indicated.
Combination w/ insulin Initially 500- or 850 mg bd-tds, adjust insulin dose based on blood glucose measurements.
Childn ≥10 yr & adolescent Monotherapy & combination w/ insulin Initially 500- or 850 mg once daily, adjusted based on blood glucose measurements after 10-15 days. Max: 2 g daily in 2 or 3 divided doses.
Renal impairment GFR 60-89 mL/min Max: 3,000 mg daily in 2-3 divided doses,
GFR 45-59 mL/min Max: 2,000 mg daily in 2-3 divided doses,
GFR 30-44 mL/min Max: 1,000 mg daily in 2-3 divided doses.
Sign Out
