Glimin Dosage/Direction for Use

Glimin Tablets 2mg are take orally.
In principle, the dosage of Glimepiride is determined by the desired blood glucose level. The dosage of Glimepiride must be the lowest which is sufficient to achieve the desired metabolic control.
Treatment with Glimepiride must be initiated and monitored by a doctor. Glimepiride must be taken at the times and in the doses prescribed. During treatment with Glimepiride glucose levels in blood and urine must be measured regularly. In addition, it is recommended that regular determinations of the proportion of glycated haemoglobin be carried out.
If it is discovered that too high a dose or an extra dose of Glimepiride has been taken, a physician must be notified immediately.
Initial dose and titration: The usual initial dose is 1mg Glimepiride once daily.
If necessary the daily dose can be increased. It is recommended that the increase be guided by regular blood glucose monitoring and that the dose be increased gradually i.e. at intervals of one to two weeks and according the following dose steps: 1mg-2mg-3mg-4mg-6mg. Daily doses of more than 6mg are more effective only in minority of patients. A maximum of 8mg day may not be exceeded.
Dose range in patient with well controlled diabetes: Usual daily doses in patient with well controlled diabetes are 1 to 4 mg Glimepiride.
Distribution of doses: Timing and distribution of doses are to be decided by the physician, taking into consideration the patient's current life-style.
Normally a single daily dose of Glimepiride is sufficient.
It is recommended that this dose be taken immediately before a substantial breakfast or-if none is taken- immediately before the first main meal.
It is very important not to skip meals after the tablet(s) have been taken.
Secondary dosage adjustment: An improvement in the control of diabetes is associated with higher insulin sensitivity therefore Glimepiride requirement may fall as treatment proceeds. To avoid hypoglycaemia, dose reduction or cessation of Glimepiride therapy must therefore be considered in time. Correction of dosage must also be considered whenever the patient's weight changes, the patients lifestyle changes or other factors arise which cause an increased susceptibility to hypoglycaemia or hyperglycaemia (refer to "Special Precautions" under Precautions).
Duration of treatment: Treatment with Glimepiride is normally long-term therapy.
Changes-over from other oral antidiabetics to Glimepiride: There is no exact dosage relationship between Glimepiride and other oral antidiabetics. When substituting Glimepiride for other oral antidiabetics, it is recommended that the procedure be the same as for initial dosage, starting with daily doses of 1mg. This applies even in case where the patient is being switched from the maximum dose of another oral antidiabetic.