In the event of an overdose, it is reasonable to employ the usual supportive measures e.g remove unabsorbed material from the gastrointestinal tract, employ clinical monitoring (including obtaining an electrocardiogram and institute supportive therapy if required. Sitagliptin is modestly dialyzable. Prolonged hemodialysis may be considered if clinically appropriate. It is not known if sitagliptin is dialyzable by peritoneal dialysis.