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Known hypersensitivity to amlodipine, valsartan, HCTZ, other sulfonamide derived medicinal products or to any of the excipients.
Pregnancy (see Use in Pregnancy & Lactation).
Severe hepatic impairment; biliary cirrhosis and cholestasis.
Severe renal impairment (creatinine clearance <30 ml/min), anuria and patients undergoing dialysis.
Refractory hypokalaemia, hyponatremia, hypercalcemia and symptomatic hyperuricemia.
Concomitant use of angiotensin receptor antagonists (ARBs) - including valsartan - or of angiotensin-converting enzyme inhibitors (ACEIs) with aliskiren in patients with Type 2 diabetes (see Valsartan: Dual blockade of the Renin-Angiotensin-System (RAS) with ARBs, ACEIs, or aliskiren under Interactions).
