Econazole: Uses, Dosage, Side Effects and More

Generic Medicine Info Patient Medicine Information

This information is not country-specific. Please refer to the Malaysia prescribing information.

Generic Medicine Info

Indications and Dosage

Topical/Cutaneous
Tinea versicolor

Adult: As 1% cream: Apply a sufficient amount onto the affected area(s) once daily. Reassess treatment if there is no improvement in symptoms after the designated treatment period. Dosage and treatment recommendations may vary between countries and individual products (refer to specific product or local official guidelines).

Topical/Cutaneous
Cutaneous candidiasis, Tinea corporis, Tinea cruris

Adult: As 1% cream: Apply a sufficient amount onto the affected area(s) bid for 2-4 weeks. Reassess treatment if there is no improvement in symptoms after the designated treatment period. Dosage and treatment recommendations may vary between countries and individual products (refer to specific product or local official guidelines).

Topical/Cutaneous
Tinea pedis

Adult: For interdigital tinea pedis: As 1% foam: Apply a sufficient amount onto the affected area(s) once daily for 4 weeks. Dosage and treatment recommendations may vary between countries and individual products (refer to specific product or local official guidelines).
Child: ≥12 years Same as adult dose. Dosage and treatment recommendations may vary between countries and individual products (refer to specific product or local official guidelines).

Topical/Cutaneous
Skin fungal infections

Adult: As 1% foaming solution: Apply onto the affected area(s) once daily in the evening for 3 consecutive days. May repeat the 3-day course after 2 weeks if infection is not resolved. Prevention of relapse: May repeat the course 1 month and 3 months after the initial treatment. Dosage and treatment recommendations may vary between countries and individual products (refer to specific product or local official guidelines).

Vaginal
Vaginal candidiasis

Adult: As pessary: Insert 1 pessary (150 mg) once daily at bedtime for 3 consecutive days. As long-acting pessary: Insert 1 pessary (150 mg) for 1 dose. Dosage and treatment recommendations may vary between individual products (refer to specific product guidelines).

What are the brands available for Econazole in Malaysia?

Econazole YSP

Contraindications

Hypersensitivity.

Special Precautions

Patient with acute porphyria, using spermicidal contraceptives (vaginal). Pregnancy and lactation.

Adverse Reactions

Significant: Irritation.
Reproductive system and breast disorders: Vaginal burning sensation, itching, discharge (vaginal).
Skin and subcutaneous tissue disorders: Erythema, itching, pruritus, burning and stinging sensation. Rarely, contact dermatitis.

Pregnancy Category (US FDA)

Topical: C

Patient Counseling Information

Topical: Avoid contact with eyes, mouth, nose, and other mucous membrane. Avoid heat, flame, and smoking during and immediately following application (foam). Vaginal cream and pessaries: May damage latex contraceptives (e.g. condoms and diaphragms); use alternative contraceptive measures.

Monitoring Parameters

Reassess diagnosis if no improvement of symptoms after completion of treatment course.

Drug Interactions

May increase serum concentration and enhance the anticoagulant effect of warfarin and acenocoumarol.

Action

Description:
Mechanism of Action: Econazole, a synthetic imidazole derivative, is an antifungal agent. It inhibits fungal CYP450-mediated enzyme, lanosterol 14α-demethylase that converts lanosterol to ergosterol resulting in alterations in membrane permeability and consequently penetrate into the cell, interfering RNA and protein synthesis and lipid metabolism.
Pharmacokinetics:
Absorption: Rapidly and minimally absorbed percutaneously. Time to peak plasma concentration: Foam: 6.8 ± 5.1 hours.
Metabolism: Cream: Metabolised in the liver into >20 metabolites.
Excretion: Cream: Via urine (<1%); faeces (<1%).

Chemical Structure

Storage

Cream: Store between 20-25°C. Foam: Store between 15-30°C. Do not refrigerate or freeze. Pessary: Store at or below 30°C. Storage recommendations may vary between individual products (refer to specific product guidelines).

MIMS Class

Preparations for Vaginal Conditions / Topical Antifungals & Antiparasites

ATC Classification

G01AF05 - econazole ; Belongs to the class of imidazole derivative antiinfectives. Used in the treatment of gynecological infections.
D01AC03 - econazole ; Belongs to the class of imidazole and triazole derivatives. Used in the topical treatment of fungal infection.

References

Anon. Econazole Nitrate. AHFS Clinical Drug Information [online]. Bethesda, MD. American Society of Health-System Pharmacists, Inc. https://www.ahfscdi.com. Accessed 02/07/2024.

Brayfield A, Cadart C (eds). Econazole. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/07/2024.

Econazole Cream 1% w/w (Sunward Pharmaceutical Sdn. Bhd.). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 02/07/2024.

Econazole Nitrate Aerosol, Foam (Resilia Pharmaceuticals, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/07/2024.

Econazole Nitrate Cream, 1% (Redpharm Drug). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed. Accessed 02/07/2024.

Econazole. UpToDate Lexidrug, Lexi-Drugs Multinational Online. Waltham, MA. UpToDate, Inc. https://online.lexi.com. Accessed 02/07/2024.

Fungi-stat Pessary (SM Pharmaceuticals Sdn Bhd). National Pharmaceutical Regulatory Agency - Ministry of Health Malaysia. https://www.npra.gov.my. Accessed 02/07/2024.

Gyno-Pevaryl 150 mg Vaginal Pessaries (Karo Pharma AB). MHRA. https://products.mhra.gov.uk. Accessed 02/07/2024.

Gyno-Pevaryl Once 150 mg Vaginal Pessary (Karo Pharma AB). MHRA. https://products.mhra.gov.uk. Accessed 02/07/2024.

iNova Pharmaceuticals (New Zealand) Limited. Pevaryl 1% w/w Cream data sheet 27 March 2018. Medsafe. http://www.medsafe.govt.nz. Accessed 02/07/2024.

iNova Pharmaceuticals (New Zealand) Limited. Pevaryl 1% w/w Foaming Solution data sheet 20 April 2018. Medsafe. http://www.medsafe.govt.nz. Accessed 02/07/2024.

Joint Formulary Committee. Econazole Nitrate. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 02/07/2024.

Pevaryl 1% Topical Cream (Karo Pharma AB). MHRA. https://products.mhra.gov.uk. Accessed 02/07/2024.

Disclaimer: This information is independently developed by MIMS based on Econazole from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2025 MIMS. All rights reserved. Powered by MIMS.com