Duromine Dosage & Drug Information

Concise Prescribing Info Full Prescribing Info Contents Description Action Indications/Uses Dosage/Direction for Use Overdosage Contraindications Special Precautions Adverse Reactions Drug Interactions Storage MIMS Class ATC Classification Regulatory Classification Presentation/Packing

Concise Prescribing Info

Contents

Phentermine (ion-exchange resin complex)

Indications/Uses

Short-term adjunct for obesity management in medically monitored comprehensive regimen of wt reduction based on exercise, diet & behaviour modification in obese (BMI ≥30 kg/m²) or overwt (BMI 25-29.9 kg/m²) patients w/ comorbidity.

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Dosage/Direction for Use

Adult & childn ≥12 yr 1 cap daily. Recommended starting dose: 30 mg daily. Recommended continuous or intermittent maintenance dose: 15-30 mg daily depending on responsiveness.

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Overdosage

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Administration

Should be taken with food: Take at breakfast. Avoid taking near bedtime. Swallow whole.

Contraindications

Known hypersensitivity to sympathomimetic drugs. Pulmonary artery HTN; existing heart valve abnormalities or heart murmurs; moderate to severe arterial HTN; cerebrovascular disease; severe cardiac disease including arrhythmias, advanced arteriosclerosis; hyperthyroidism; agitated states or history of psychiatric illness including anorexia nervosa & depression; glaucoma; history of drug/alcohol abuse or dependence. Concomitant use w/ MAOIs or w/in 14 days of administration.

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Special Precautions

Valvular heart disease; primary pulmonary HTN. Mild HTN, diabetes, established CAD, epilepsy, patients receiving psychotropic drugs including sedatives & sympathomimetics, antihypertensives. Require medical review at least every 3 mth. Wt loss should be gradual & controlled. Not to be combined w/ other appetite suppressants. Not recommended w/ drug products for wt loss; SSRIs, ergot-like drugs & clomipramine. Concomitant use w/ fenfluramine or dexfenfluramine. May affect ability to drive & use machines. Not to be used during pregnancy. Avoid use during lactation. Not recommended in childn <12 yr & elderly.

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Adverse Reactions

Palpitations, tachycardia, elevated BP, precordial pain. Overstimulation, restlessness, nervousness, insomnia, tremor, dizziness, headache; nausea, vomiting, dry mouth, abdominal cramps, unpleasant taste, diarrhoea, constipation; micturition disturbances, rash, impotence, changes in libido, facial oedema.

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Drug Interactions

Antagonised adrenergic neurone blockers eg, clonidine, methyldopa, guanethidine. Potentiated effects by MAOIs. Increased CNS stimulation w/ thyroid hormones. Increased CNS side effects w/ alcohol. Caution use w/ sympathomimetics.

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Storage

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Description

View Duromine description for details of the chemical structure and excipients (inactive components).

Action

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MIMS Class

Anti-Obesity Agents

ATC Classification

A08AA01 - phentermine ; Belongs to the class of centrally acting antiobesity products. Used in the treatment of obesity.

Regulatory Classification

Presentation/Packing

Form

Duromine cap 15 mg

Packing/Price

30's

Form

Duromine cap 30 mg

Packing/Price

30's

Duromine

phentermine

Manufacturer:

iNova

Distributor:

Zuellig Pharma